Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak
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Anahtar Kelimeler

tırnak
Tırnak
toksikolojik analiz
Toksikolojik analiz
yorumlama
Yorumlama

Nasıl Atıf Yapmalı

1.
Efeoğlu Özşeker P, Dağlıoğlu N. Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. Adli Tıp Bülteni. 2018;23(1):47-52. DOI: https://doi.org/10.17986/blm.2017332889

Öz

Son zamanlarda hassas ve seçici analitik tekniklerin gelişmesiyle beraber alternatif biyolojik örneklerin kullanımı artmıştır. Özellikle dekompoze ve pütrifiye olmuş postmortem vakalarda ya da kan veya idrar örneklerinin alınamadığı durumlarda saç ve tırnak gibi keratin yapılı biyolojik örnekler adli ve klinik toksikologların ilgisini çekmiştir.

İlaçlar, kimyasallar, uyutucu-uyuşturucu maddeler, ağır metaller uzun dönem saçta ve tırnakta birikebilmektedir. Geçmişe dönük kullanımda iyi bir belirteç olan saç örneğinin yetersiz olduğu durumlarda toksikolojik analiz için tırnak örneği yararlı olabilmektedir. Tırnak matrisinin kompleks yapısı ve tırnakta tespit edilen ilaç konsantrasyonunun düşük olması nedeniyle numune hazırlama işlemi ve kullanılacak olan analitik yöntemler önemlidir.

Bu çalışmada toksikolojik analizlerde alternatif olarak kullanılan tırnağın anatomik yapısı, tırnak analizlerindeki analitik yöntemler, tırnak kullanımın avantajları/dezavantajları ve analiz sonuçların nasıl yorumlanacağı incelenecektir.

https://doi.org/10.17986/blm.2017332889
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Kaynaklar

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