Evaluation of the effects of intravenous lipid emulsion and ethanol on the optic nerve and retina in methanol-intoxicated rats: a histopathological study
DOI:
https://doi.org/10.17986/blm.1750Keywords:
methanol intoxication, ethanol, intravenous lipid emulsion, optik nerveAbstract
Objective: The objective of this study was to evaluate the efficacy of intravenous lipid emulsion (ILE) application in comparison to ethanol in the treatment of optic neuropathy resulting from acute methanol intoxication in rats.
Methods: 64 male rats were divided into 7 groups: Group 1 (control group), Group 2 (methanol group), Group 3 (methanol + ethanol group), Group 4 (methanol + ILE group), Group 5 (methanol + ethanol + ILE group), Group 6 (ethanol group), and Group 7 (ILE group). Blood samples were taken to analysis liver and kidney function. The rats were sacrificed. The optic nerve and retina were examined histologically.
Results: The combination of methanol, ethanol, and ILE has a positive effect on LDH and CK-MB levels. Histopathologically, marked vascularization and vacuolization were observed in the optic nerve in the methanol group. These changes were not significant in the group receiving methanol, intravenous lipid emulsion, and ethanol together. ILE and ethanol did not cause any significant apoptotic changes in the retina (p=0.357). Significant edema, vascularization, apoptotic changes, and vacuolization were observed in the retinal tissue in the methanol group. These effects were not observed in the methanol + ILE and methanol + ILE +ethanol groups compared to the control group.
Conclusion: The combination of methanol, ethanol, and ILE has a beneficial effect, especially on cardiac damage. Histopathologically, the combination of methanol + ethanol + ILE reduces the negative effects of methanol on the optic nerve and retina.
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Copyright (c) 2025 Doç.Dr.Muhammet CAN- Dr.Öğretim Üyesi Hümeyra Yıldırım- Doç.Dr.Özgür Bulmuş- Doç.Dr.Gülay TURAN- prof.Dr.Cengiz Gökbulut- Prof.Dr.Adnan adil Hismioğulları- Dr.Mustafa Hilmi Yaranoğlu
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