Keywords
cellularity
aging
Abstract
Knowledge of the normal variations with aging of the bone marrow cellularity is essential for the interpretation of bone marrow features. We performed a histological study using biopsy samples of bone marrow obtained from medicolegal autopsies ranging from first to eighth decades. As a matter of increasing age, an increasing fat tissue fraction was observed.
Key words: Bone marrow, cellularity, aging.
References
Naeim F, Nimer S. Bone marrow structure and function. Pathology of Bone Marrow, ed. Naeim F, Igaku-shoin, Tokyo, 1992; 1-2.
McKenna RW, Maiese RL, Kroft SH. Disorders of bone marrow. Diagnostic Surgical Pathology, ed.Sternberg SS, 3rd ed., Lippincott Williams & Wilkins, Philadelphia,1999;651-654.
Rothstein G. Origin and development of the blood and blood-forming tissues. Wintrobe’s Clinical Hematology, ed. Lee RG, Bithell TC, Foerster J, Athens JW, Lukens JN, 8th ed., Lea&Febiger, Philadelphia, 1993; 66-67.
Takafumi O, Kitagawa M, Plirokawa K. Age-related changes of human bone marrow, a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mechanism of ageing and Development 2000;l-3: 57-68.
Wickramasinghe SN, McCullough J. Normal bone marrow cells, development cytology and ultrastructure. Blood and Bone Marrow Pathology, Churchill Livingstone, Chine, 2000; 24.
Custer RP, Ahlfeldt FE. Studies on structure and functions of bone marrow. J. Lab.Clin. Med 1932; 17: 960-962.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2003 Elif Ülker Akyıldız- Hilal Akı- Safa Çelik