Death Due to Tianeptine Injection Through Inguinal Incision: Two Case Reports

  • Hüseyin Çetin Ketenci Adli Tıp Kurumu Trabzon Adli Tıp Grup Başkanlığı
  • Emel Çakır Karadeniz Technical University, Medical Faculty, Department of Pathology, Trabzon
  • Nazım Ercüment Beyhun Karadeniz Technical University Medical Faculty, Department of Public Health, Trabzon
  • Halil Boz The Council of Forensic Medicine, Trabzon Group Chairmanship, Trabzon
  • Hasan Okumuş The Council of Forensic Medicine, Malatya Group Chairmanship, Malatya
  • Gökhan Cingöz The Council of Forensic Medicine, İzmir Group Chairmanship, İzmir
  • Bülent Şam The Council of Forensic Medicine, İstanbul
Keywords: Tianeptine, Autopsy, Inguinal incision, Injection

Abstract

In recent years, drug use has come to the forefront as one of the most important problems of public health. Tianeptine is an antidepressant that is structurally similar to tricyclic antidepressants and is used for the treatment of depression but is also abused because its pleasing feature has been recognized by drug users. Two forensic cases were autopsied with an interval of 25 days. One case had unilateral unusual inguinal lesions. The other case bilateral unusual inguinal lesions. It was understood that these lesions were preformed, improved surgical catheter incisions in order to facilitate intravenous injections for drug abuse. This application, which was detected in the inguinal region, was found to be interesting. It is aimed to raise the awareness of this application, which is not found in the literature. As a result of the intense human transit, substance abuse habits and methods have also been transferred to citizens...

Downloads

Download data is not yet available.

References

European Monitoring Center for Drugs and Drug Addiction [cited 2017 Aug 11]. Available from: http://www.emcdda.europa.eu/system/files/publications/4502/TD0116924ENN.pdf_en

Vukovic O, Maric NP, Britvic D, Cvetic T, Damjanovic A, Prostran M, Miroslava JG. Efficacy, tolerability and safety of tıaneptine in special populations of depressive patients, Psychiatria Donubina. 2009;21:194-198

Saatciogli O, Erim R, Cakmak D. Tiyaneptin kotuye kulanimi: bir olgu sunumu, Turkish Journal of Psychiatry. 2006;17:72-75

Gassaway MM, Rives ML, Kruegel AC, Javitch JA, Sames D. The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist, Translational Psychiatry. 2014; 4: e411

Malka R, Loo H, Ganry H, Souche A, MareyC, Kamoun A. Long-term administration tianeptine in depressed patients after alcohol withdrawal. Br J Psychiatry 1992;15: 66-71

Kasper S, Olie JP. A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression. Eur Psychiatry. 2002;17: 331-340

McEwen BS, Chattarji S, Diamond DM, Jay TM, Reagen LP, Svenningson P, Fuchs E. The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation, Molecular Psychiatry. 2010;15: 237-249

Lapsekili N, Yavuz KF. Tianeptin bagimliligi: bir olgu sunumu, Dusunen Adam, The Journal of Psychiatry and Neurological Sciences. 2014; 27;81-84

Yuksel N. Tianeptin: depresyon ve eslik eden anksiyete tedavisindeki yeri, Klinik Psikiyatri. 2004; 4: 25-31

Labrid C, Mocaer E, Kamoun A. Neurochemical and pharmacological properties of tianeptine, a novel antidepressant. Br J Psychiatry. 1992;160:56-60

Wagstaff AJ, Ormrod D, Spencer CM. Tianeptine: a review of its use in depressive disorders. CNS Drugs. Adis Drug Evaluation. 2001;15: 231-259

Proenca P, Teixeira H, Pinheiro J, MonsantoPV, Vieira DN. Fatal intoxication with tianeptine (Stablon®), For. Sci. Int. 2007; 170: 200–203

Talking Drugs. Coaxil madness in Russia. [cited 2017 Aug 11] Available from: http://www.talkingdrugs.org/prescription-drug-madness-in-russia

Ilhan G, Ergene S, Durakoglugil T, Karamustafa H, Karakisi O, Bozok S. Bilateral pseudo aneurysm secondary to intraarterial tianeptine abuse, The Anatolian Journal of Cardiology. 2013;13:812-815

Ferreira MJ, Costa EV, Fonseca L, Pissarra, Oliveira CJ. Abuse of Tianeptine: A case report. European Psychiatry. 23 (2008), pp. 308-309

Vadachkoria D, Gabunia L, Gambashidze K, Pkhaladze N, Kuridze N. Addictive Potential of Tianeptine-The Threatening Reality. Georgian Med New. 2009;174: 92-94

Sen A, Ilhan G, Tomak Y, Erdivanlı B, Ersoz T, Ergene MS. Role of Cultural Interaction in Tianeptine Abuse and Different Application Methods. Turk J Anaesth Reanim. 2013;41:229-231

Karimi M, Ghaheri H, Assari S, Ahmadi K, Moghani Lankarani M, Moghani Lankarani R, Narenjiha H, Rafiey H, Tavakoli M, Jafari F. Drug Injection to Sites other than Arm: A Study of Iranian Heroin Injectors. Front Psychiatry. 2014;5:23

Hope VD, Scott J, Cullen KJ, Parry JV, Ncube F, Hickman M. Going into the groin: Injection into the femoral vein among people who inject drugs in three urban areas of England. Drug Alcohol Depend. 2015;152:239-45

Darke S, Ross J, Kaye S. Physical injecting sites among injecting drug users in Sydney, Australia. Drug Alcohol Depend. 2001;62(1):77-82

Published
2018-03-30
How to Cite
Ketenci, H., Çakır, E., Beyhun, N., Boz, H., Okumuş, H., Cingöz, G., & Şam, B. (2018). Death Due to Tianeptine Injection Through Inguinal Incision: Two Case Reports. The Bulletin of Legal Medicine, 23(2), 123-128. https://doi.org/10.17986/blm.2018238626
Section
Case Reports

Most read articles by the same author(s)