Death Due to Tianeptine Injection Through Inguinal Incision: Two Case Reports
In recent years, drug use has come to the forefront as one of the most important problems of public health. Tianeptine is an antidepressant that is structurally similar to tricyclic antidepressants and is used for the treatment of depression but is also abused because its pleasing feature has been recognized by drug users. Two forensic cases were autopsied with an interval of 25 days. One case had unilateral unusual inguinal lesions. The other case bilateral unusual inguinal lesions. It was understood that these lesions were preformed, improved surgical catheter incisions in order to facilitate intravenous injections for drug abuse. This application, which was detected in the inguinal region, was found to be interesting. It is aimed to raise the awareness of this application, which is not found in the literature. As a result of the intense human transit, substance abuse habits and methods have also been transferred to citizens...
European Monitoring Center for Drugs and Drug Addiction [cited 2017 Aug 11]. Available from: http://www.emcdda.europa.eu/system/files/publications/4502/TD0116924ENN.pdf_en
Vukovic O, Maric NP, Britvic D, Cvetic T, Damjanovic A, Prostran M, Miroslava JG. Efficacy, tolerability and safety of tıaneptine in special populations of depressive patients, Psychiatria Donubina. 2009;21:194-198
Saatciogli O, Erim R, Cakmak D. Tiyaneptin kotuye kulanimi: bir olgu sunumu, Turkish Journal of Psychiatry. 2006;17:72-75
Gassaway MM, Rives ML, Kruegel AC, Javitch JA, Sames D. The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist, Translational Psychiatry. 2014; 4: e411
Malka R, Loo H, Ganry H, Souche A, MareyC, Kamoun A. Long-term administration tianeptine in depressed patients after alcohol withdrawal. Br J Psychiatry 1992;15: 66-71
Kasper S, Olie JP. A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression. Eur Psychiatry. 2002;17: 331-340
McEwen BS, Chattarji S, Diamond DM, Jay TM, Reagen LP, Svenningson P, Fuchs E. The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation, Molecular Psychiatry. 2010;15: 237-249
Lapsekili N, Yavuz KF. Tianeptin bagimliligi: bir olgu sunumu, Dusunen Adam, The Journal of Psychiatry and Neurological Sciences. 2014; 27;81-84
Yuksel N. Tianeptin: depresyon ve eslik eden anksiyete tedavisindeki yeri, Klinik Psikiyatri. 2004; 4: 25-31
Labrid C, Mocaer E, Kamoun A. Neurochemical and pharmacological properties of tianeptine, a novel antidepressant. Br J Psychiatry. 1992;160:56-60
Wagstaff AJ, Ormrod D, Spencer CM. Tianeptine: a review of its use in depressive disorders. CNS Drugs. Adis Drug Evaluation. 2001;15: 231-259
Proenca P, Teixeira H, Pinheiro J, MonsantoPV, Vieira DN. Fatal intoxication with tianeptine (Stablon®), For. Sci. Int. 2007; 170: 200–203
Talking Drugs. Coaxil madness in Russia. [cited 2017 Aug 11] Available from: http://www.talkingdrugs.org/prescription-drug-madness-in-russia
Ilhan G, Ergene S, Durakoglugil T, Karamustafa H, Karakisi O, Bozok S. Bilateral pseudo aneurysm secondary to intraarterial tianeptine abuse, The Anatolian Journal of Cardiology. 2013;13:812-815
Ferreira MJ, Costa EV, Fonseca L, Pissarra, Oliveira CJ. Abuse of Tianeptine: A case report. European Psychiatry. 23 (2008), pp. 308-309
Vadachkoria D, Gabunia L, Gambashidze K, Pkhaladze N, Kuridze N. Addictive Potential of Tianeptine-The Threatening Reality. Georgian Med New. 2009;174: 92-94
Sen A, Ilhan G, Tomak Y, Erdivanlı B, Ersoz T, Ergene MS. Role of Cultural Interaction in Tianeptine Abuse and Different Application Methods. Turk J Anaesth Reanim. 2013;41:229-231
Karimi M, Ghaheri H, Assari S, Ahmadi K, Moghani Lankarani M, Moghani Lankarani R, Narenjiha H, Rafiey H, Tavakoli M, Jafari F. Drug Injection to Sites other than Arm: A Study of Iranian Heroin Injectors. Front Psychiatry. 2014;5:23
Hope VD, Scott J, Cullen KJ, Parry JV, Ncube F, Hickman M. Going into the groin: Injection into the femoral vein among people who inject drugs in three urban areas of England. Drug Alcohol Depend. 2015;152:239-45
Darke S, Ross J, Kaye S. Physical injecting sites among injecting drug users in Sydney, Australia. Drug Alcohol Depend. 2001;62(1):77-82
Copyright (c) 2018 Hüseyin Çetin Ketenci, Emel Çakır, Nazım Ercüment Beyhun, Halil Boz, Hasan Okumuş, Gökhan Cingöz, Bülent Şam
This work is licensed under a Creative Commons Attribution 4.0 International License.
The Bulletin of Legal Medicine is an open access scientific journal. Open access means that all content is freely available without charge to the user or his/her institution on the principle that making research freely available to the public supports a greater global exchange of knowledge. The Journal and content of this website is licensed under the terms of the Creative Commons Attribution (CC BY) License. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access.
The Creative Commons Attribution License (CC BY) allows users to copy, distribute and transmit an article, adapt the article and make commercial use of the article. The CC BY license permits commercial and non-commercial re-use of an open access article, as long as the author is properly attributed.
The Bulletin of Legal Medicine requires the author as the rights holder to sign and submit the journal's agreement form prior to acceptance. The authors retain copyright of their work and grant the Association for its publication. This ensures both that The Journal has the right to publish the article and that the author has confirmed various things including that it is their original work and that it is based on valid research.
Authors who publish with this journal agree to the following terms:
*Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
*Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
*Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.